About this condition

Overactive Bladder (OAB) is a syndrome characterized by frequent, sudden and desperate need to urinate, with or without urgency-associated urinary incontinence, which interferes with normal daily activities. Worldwide, roughly 136 million adults (16% prevalence rate – 2/3rds are working age in the developed world) are estimated to have OAB [1]. The US annual healthcare burden with OAB is estimated at $25 billion per year [2].

[1] Stewart WF. Prevalence and Burden of Overactive Bladder in the Unites States. World J Urol (2003) 20:327-33;,

[2] The Total Economic Burden of Overactive Bladder in the United States: A Disease-Specific Approach AM J Manag Care. 2009;15:S90-S97

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OAB and the coping strategies used to manage or hide OAB symptoms affect interactions with friends, colleagues, and families. Notable psychological effects of OAB and urinary incontinence include fear, shame, and guilt. Studies of the impact of OAB and urinary incontinence demonstrate decreased levels of social and personal activities, increased psychological distress, and an overall decrease in Quality of Life (QOL) [1].

Treatments include bladder training and pelvic floor exercises, which are two behavioral therapy treatments for overactive bladder that are used as an initial treatment for most patients.

Other forms of treatment include: pharmacological treatment with anticholinergics to block nerve signals, Botox injections to relax the bladder muscle and sacral neuromodulation through an implant to deliver mild electrical impulses to the sacral nerves.

Amphora Medical is developing a minimally invasive therapy to treat OAB.  The therapy has the potential to provide lasting symptom relief in OAB patients by treating the bladder nerves. The treatment is under clinical investigation and is not yet commercially available.

[1] Stewart WF. Prevalence and Burden of Overactive Bladder in the Unites States. World J Urol (2003) 20:327-33;,

 

For more information about OAB 

For current OAB treatment options, please consult a healthcare professional.